作者：张青松；查刘生，马敬红，梁伯润
关键字：微凝胶；敏感性；半连续
论文来源：期刊
具体来源：Journal of Colloid and Interface Science
发表时间：2009年

A novel method via a semibatch process in the absence of surfactant has been adopted to prepare pH- and temperature-sensitive nanogels. The shape, charge distribution, temperature, and pH-induced volume phase transition behavior of the latexes were investigated by scanning electronic microscopy, zeta potentials, dynamic laser light scattering, and UV/vis spectroscopy. It was found that, in the absence of surfactant, with increasing the amount of AAc from 5 to 20 mol% of N-isopropylacrylamide (NIPAM), the hydrodynamic diameters (DH) decrease from 230 to 60 nm. With increasing pH value from 3 to 11, the DH values increase slightly, which is different than the dramatic increase seen when using a conventional
batch method with a range from 680 to 1700 nm. However, at pH 3, the turbidity curves of these kinds of particles increase dramatically at temperatures between 33 and 37^?C, while remaining constant at first and then increasing directly at pH 11. Furthermore, the distribution of carboxylic groups located not only on the interior but also on the exterior of colloidal particles as a result of adoption of the semibatch
method, other than simple surface distribution of poly(NIPAM-co-AAc) latexes via the batch method.